6-溴-2,3-二氢喹啉-4(1H)-酮合成路线 （共 8 条）
参考文献
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
Patent: WO2009/39553 A1, 2009 ;
Location in patent: Page/Page column 93 ;
反应条件
N-bromosuccinmide in dichloromethane T=20°C; 1.5 h;
参考文献
WO2005/95326 A2, ;
Page/Page column 248 ;
WO 2005/095326 A2
反应条件
trifluorormethanesulfonic acid in dichloromethane T=0 - 18°C; Fries rearrangement; 1 h; Inert atmosphere;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
trichlorophosphate T=100°C; anschliessenden Behandeln mit wss. Natronlauge;
参考文献
Journal of the American Chemical Society, , vol. 76, p. 5065,5067
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed 2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere View Scheme
参考文献
Australian Journal of Chemistry, , vol. 64, # 4 p. 454 - 470
反应条件
1: 30 percent / ethylmagnesium bromide / tetrahydrofuran / 14 h 2: 30 percent / trifluoroacetic acid / 1.5 h / 100 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2105 - 2111
反应条件
1: conc. hydrochloric acid / ethanol / 48 h / Heating 2: 30 percent / ethylmagnesium bromide / tetrahydrofuran / 14 h 3: 30 percent / trifluoroacetic acid / 1.5 h / 100 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2105 - 2111
反应条件
lithium aluminium tetrahydride; aluminium trichloride in tetrahydrofuran T=60°C;
参考文献
Varnes, Jeffrey G.; Wacker, Dean A.; Jacobson, Irina C.; Quan, Mimi L.; Ellis, Christopher D.; Rossi, Karen A.; He, Ming Y.; Luettgen, Joseph M.; Knabb, Robert M.; Bai, Steven; He, Kan; Lam, Patrick Y.S.; Wexler, Ruth R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6481 - 6488
