6-溴二氮杂萘-1,4-二醇合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; trichlorophosphate
参考文献
Harper, Steven; Summa, Vincenzo; Liverton, Nigel J.; McCauley, John A.; Butcher, John W.; Di Filippo, Marcello; Di Francesco, Maria Emilia; Ferrara, Marco; Romano, Joseph J.; Rudd, Michael T.
Patent: US2010/183551 A1, 2010 ;
反应条件
1: With trichlorophosphate 3 h; Heating / reflux; 2: With sodium hydroxide; water in 1,4-dioxane T=50°C; 0.5 h; Product distribution / selectivity;
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: WO2008/61108 A2, 2008 ;
Location in patent: Page/Page column 78 ;
反应条件
1: With thionyl chloride; trichlorophosphate 4 h; Heating / reflux; 2: With sodium hydroxide; water in 1,4-dioxane T=40°C; 2.5 h; Product distribution / selectivity;
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: WO2008/61108 A2, 2008 ;
Location in patent: Page/Page column 66 ;
反应条件
hydrazine hydrate; acetic acid
T=125°C; 0.5 h;
参考文献
Han, Junyan; Jose, Jiney; Mei, Erwen; Burgess, Kevin
Angewandte Chemie - International Edition, 2007 , vol. 46, # 10 p. 1684 - 1687
