1-苄氧基-2-氟-4-硝基苯合成路线 （共 5 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=40°C;
参考文献
EXELIXIS, INC.
Patent: WO2006/108059 A1, 2006 ;
Location in patent: Page/Page column 90-91 ;
WO 2006/108059 A1
反应条件
1: benzyl alcohol With sodium hydride in isobutyramide
T=20°C; 1 h;
2: 1,2-difluoro-4-nitrobenzene in isobutyramide
T=0°C; 1 h;
参考文献
EXELIXIS, INC.
Patent: WO2005/30140 A2, 2005 ;
Location in patent: Page/Page column 203 ;
WO 2005/030140 A2
反应条件
sodium methylate in dimethyl sulfoxide
参考文献
Sterling Drug Inc.
Patent: US4224335 A1, 1980 ;
反应条件
potassium hydroxide in dichloromethane; water
T=20°C; 3 h;
参考文献
MORPHOCHEM AG
Patent: WO2005/23801 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 2 h;
参考文献
Chen, Dong; Zhai, Xin; Yuan, Qiu Hui; Luo, Jian; Xie, Si Chang; Gong, Ping
Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1326 - 1329
