5-氰基-3,4-二氢-2H-吡喃-2-羧酸合成路线 （共 6 条）
反应条件
hydrogenchloride; sodium hydroxide; hydrogen 1.) methanol, RT; 2.) 0 deg C, 10 min and 0.5 h, RT; Multistep reaction. Title compound not separated from byproducts;
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
反应条件
hydrogenchloride; sodium hydroxide; hydrogen 1.) methanol, RT; 2.) 0 deg C, 10 min and 0.5 h, RT; 3.) methanol; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
反应条件
sodium hydroxide
Ambient temperature;
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
反应条件
1: 52 percent / c. NH4OH / benzene / 1 h / 9 - 10 °C
2: 87 percent / 16 percent HCl / 1 h / Heating
3: 68 percent / p-TsCl, pyridine / 80 °C
4: 85 percent / 2 N NaOH / Ambient temperature
View Scheme
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
反应条件
1: 87 percent / 16 percent HCl / 1 h / Heating
2: 68 percent / p-TsCl, pyridine / 80 °C
3: 85 percent / 2 N NaOH / Ambient temperature
View Scheme
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
反应条件
1: 68 percent / p-TsCl, pyridine / 80 °C
2: 85 percent / 2 N NaOH / Ambient temperature
View Scheme
参考文献
Isoda; Yamaguchi; Satoh; Hirata
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2329 - 2336
