2-((叔丁基二苯基甲硅烷基)氧基)乙酸合成路线 （共 6 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane Reflux;
参考文献
Ascenso, Osvaldo S.; Marques, Joao C.; Santos, Ana Rita; Xavier, Karina B.; Rita Ventura; Maycock, Christopher D.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1236 - 1241
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran
T=20°C;
2: With hydrogenchloride; water
参考文献
Ascenso, Osvaldo S.; Marques, Joao C.; Santos, Ana Rita; Xavier, Karina B.; Rita Ventura; Maycock, Christopher D.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1236 - 1241
反应条件
4-(N,N-dimethlyamino)pyridine; chloro-trimethyl-silane; triethylamine in tetrahydrofuran
T=0 - 25°C; 10 h;
参考文献
Nicolaou; Snyder, Scott A.; Huang, Xianhai; Simonsen, Klaus B.; Koumbis, Alexandros E.; Bigot, Antony
Journal of the American Chemical Society, 2004 , vol. 126, # 32 p. 10162 - 10173
反应条件
methanol; water; potassium carbonate in tetrahydrofuran
T=20°C; 3.5 h;
参考文献
Fanjul, Sandra; Hulme, Alison N.
Journal of Organic Chemistry, 2008 , vol. 73, # 24 p. 9788 - 9791
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Banker, Pierette; Cadilla, Rodolfo; Lambert lll, Millard Hurst; Rafferty, Stephen William; Sternbach, Daniel David; Sznaidman, Marcos Luis
Patent: US2004/72838 A1, 2004 ;
US 20040072838 A1
反应条件
1: Et3N; DMAP / CH2Cl2 / 1 h / 20 °C
2: 1.76 g / K2CO3 / tetrahydrofuran; H2O / 1 h / 20 °C
View Scheme
参考文献
Craig, Donald; Ford, Mark J.; Gordon, Richard S.; Stones, James A.; White, Andrew J. P.; Williams, David J.
Tetrahedron, 1999 , vol. 55, # 52 p. 15045 - 15066
