外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺合成路线 （共 32 条）
反应条件
ethanol; sodium 16 h; Heating;
参考文献
Bagley; Riley
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 3 p. 485 - 488
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=20°C; 2 h; Inert atmosphere;
参考文献
Asano, Shigehiro; Gavrilyuk, Julia; Burton, Dennis R.; Barbas, Carlos F.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 2 p. 133 - 137
反应条件
sodium in pentan-1-ol T=80°C; Heating;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 91 percent / Hydroxylamine hydrochloride, sodium bicarbonate / aq. ethanol / 0.5 h / 100 °C 2: 66 percent / Sodium, ethanol / 16 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 485 - 488
反应条件
2: NH2OH*HCl / 0.67 h 3: 80 percent / Na / pentan-1-ol / 80 °C / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 2 p. 105 - 110
反应条件
1: NH2OH*HCl / 0.67 h 2: 80 percent / Na / pentan-1-ol / 80 °C / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 2 p. 105 - 110
反应条件
1.1: hydrogenchloride; water / 1 h / Reflux 1.2: 6 h / 0 - 50 °C 1.3: pH 12 2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux 3.1: sodium; pentan-1-ol / 2 h / Reflux View Scheme
参考文献
US2011/251192 A1, ;
US 20110251192 A1
反应条件
sodium in pentan-1-ol; toluene 0.25 h; RefluxInert atmosphere; Overall yield = 95 percent; Overall yield = 18 g;
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1094 - 1103
反应条件
1: With potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide T=65 - 70°C; 4.25 h; 2: With sulfuric acid; water in toluene T=20°C; 1 h; 3: With sodium hydroxide in water; toluene pH=8.0 - 12.7; Product distribution / selectivity;
参考文献
WO2005/37831 A1, ;
Page/Page column 12-13 ;
反应条件
1.1: sodium carbonate / dichloromethane; water / 2 h / 0 - 20 °C 2.1: phosphorus pentachloride / dichloromethane / 2 h / 10 - 20 °C / Cooling with ice 2.2: 10 - 20 °C 2.3: pH 12 / Cooling with ice 3.1: ammonium formate / palladium 10 on activated carbon / ethanol / 12 h / Reflux; Inert atmosphere View Scheme
参考文献
US2011/251192 A1, ;
US 20110251192 A1
