外向-3-氨基-9-甲基-9-氮杂双环[3,3,1]壬烷合成路线 （共 7 条）
反应条件
ammonia; rhodium in methanol
参考文献
SmithKline Beecham p.l.c.
Patent: US5856489 A1, 1999 ;
反应条件
hydrogenchloride; triethylamine in dichloromethane
参考文献
Beecham Group p.l.c.
Patent: US4886808 A1, 1989 ;
反应条件
triethylamine in dichloromethane 2 h;
参考文献
Chemagis Ltd.
Patent: EP1484321 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1: 1H-indazole-3-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane; N,N-dimethyl-formamide T=20°C; 2 h; 2: (endo)-3-amino-9-methyl-9-azabicyclo[3.3.1]nonane in dichloromethane; N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestr, Linda; Lummis, Sarah C. R.; Lochner, Martin
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2324 - 2328
反应条件
in N,N-dimethyl-formamide
参考文献
Beecham Group p.l.c.
Patent: US4886808 A1, 1989 ;
反应条件
in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929
反应条件
triethylamine in dichloromethane 2 h; Yield given;
参考文献
Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929
