4-溴-2-氟苄溴合成路线

51436-99-84-溴-2-氟甲苯

76283-09-54-溴-2-氟苄溴

参考文献

Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2938 - 2945

76283-09-54-溴-2-氟苄溴

193290-19-6(4-溴-2-氟苯基)乙酸甲酯

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Daiichi Sankyo Company, Limited
Patent: EP1806332 A1, 2007 ;

151-50-8氰化钾+

76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

参考文献

Sankyo Company, Limited
Patent: EP1764075 A1, 2007 ;
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773837-37-9+

76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

参考文献

Daiichi Sankyo Company, Limited; MORI, Makoto; FUJII, Kunihiko; INUI, Masaharu; BABA, Takayuki; ONISHI, Yukari; AOYAGI, Atsushi
Patent: EP2700643 A1, 2014 ;
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143-33-9氰化钠+

76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

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PFIZER INC.
Patent: WO2006/18725 A1, 2006 ;
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WO 2006/018725 A1

114897-91-52-氟-4-溴苯乙腈

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PFIZER INC.
Patent: WO2004/74270 A2, 2004 ;
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76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

参考文献

Clemens, James Allen; Lodge, David
Patent: US2004/63680 A1, 2004 ;

13435-20-6氰化四乙基铵+

76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

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BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1916239 A1, 2008 ;
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EP 1916239 A1

773837-37-9+

76283-09-54-溴-2-氟苄溴

1000668-71-2+

114897-91-52-氟-4-溴苯乙腈

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GLAXOSMITHKLINE LLC; GHERGUROVICH, Jonathan, Michael; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; RIDGERS, Lance, Howard; YU, Hongyi
Patent: WO2013/28447 A1, 2013 ;
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180330-54-5+

76283-09-54-溴-2-氟苄溴

114897-91-52-氟-4-溴苯乙腈

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Daiichi Sankyo Company, Limited
Patent: EP1806332 A1, 2007 ;