1: With sodium ethanolate in ethanol
12 h;
2: With sodium hydroxide in ethanol; water
12 h;
3: With hydrogenchloride in diethyl ether; water
参考文献
Zhang, Wei; Benmohamed, Radhia; Arvanites, Anthony C.; Morimoto, Richard I.; Ferrante, Robert J.; Kirsch, Donald R.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 1029 - 1045
1: EtONa / ethanol / 6 h / Heating
2: 2 N NaOH / 2 h / Heating
3: 5 N H2SO4 / 4.5 h / Heating
View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
