3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
2: 1) n-BuLi, HMPA / 1) THF, hexane, 30 min, -78 deg C, 2) THF, to r.t., overnight
3: 86 percent / sodium periodate / methanol / 25 °C / other solvent: phosphate buffer (pH 7)
View Scheme
参考文献
Ishihara, Kazuaki; Mori, Atsunori; Yamamoto, Hisashi
Tetrahedron, 1990 , vol. 46, # 13/14 p. 4595 - 4612
反应条件
sodium hydrogen sulphate in water; toluene
T=110 - 115°C; 21.5 h; Dean-Stark;
参考文献
BASF SE; Heidemann, Thomas; Königsmann, Lucia
Patent: US2013/109867 A1, 2013 ;
Location in patent: Paragraph 0083 ;
反应条件
1: 2-methyl-4-hydroxy-1-butene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
T=20°C; 6 h;
2: prenyl bromide in diethyl ether
T=-78 - 20°C; Further stages.;
参考文献
Yong, Kelvin H.; Lotoski, John A.; Chong, J. Michael
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8248 - 8251
反应条件
Montmorillonite K 10
T=20°C; 216 h; Further byproducts given;
参考文献
Desaubry, Laurent; Nakatani, Yoichi; Ourisson, Guy
Tetrahedron Letters, 2003 , vol. 44, # 36 p. 6959 - 6961
反应条件
Montmorillonite K 10
T=20°C; 216 h; Further byproducts given;
参考文献
Desaubry, Laurent; Nakatani, Yoichi; Ourisson, Guy
Tetrahedron Letters, 2003 , vol. 44, # 36 p. 6959 - 6961
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 0.333333 h; reaction with isopentenyl derivatives and their homologs in var. solvents; Product distribution;
参考文献
Badet,B.; Julia,M.; Mallet,J.M.
Tetrahedron, 1988 , vol. 44, p. 2913
反应条件
1: 93 percent / PTSA / 1 h / 0 °C
2: K3Fe(CN)6; K2CO3; OsO4 / (DHQD)2-PHAL / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
3: SOCl2; Et3N / CH2Cl2 / 0.33 h / 0 °C
4: NaIO4; RuCl3*H2O / dimethylsulfoxide; acetonitrile; H2O / 2 h / 0 °C
5: dimethylformamide / 8 h / 80 °C
6: aq. H2SO4 / ethanol / 18 h / Heating
View Scheme
参考文献
Herold; Mohr; Tamm
Helvetica Chimica Acta, 1983 , vol. 66, # 3 p. 744 - 754
反应条件
1: 92 percent / pyridine / CH2Cl2 / 0.25 h / -50 - -40 °C
2: 1.) NaH, 2.) N-butyllithium
3: 1.) NaH / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT
4: MeCu / tetrahydrofuran / 3 h / -25 °C
5: DIBAL / diethyl ether; hexane / 2 h / 0 °C
View Scheme
参考文献
Alderdice; Spino; Weiler
Canadian Journal of Chemistry, 1993 , vol. 71, # 11 p. 1955 - 1963
反应条件
1: 92 percent / pyridine / CH2Cl2 / 0.25 h / -50 - -40 °C
2: 1.) NaH, 2.) N-butyllithium
View Scheme
参考文献
Alderdice; Spino; Weiler
Canadian Journal of Chemistry, 1993 , vol. 71, # 11 p. 1955 - 1963
反应条件
potassium carbonate
2.) methanol, 1h, room temperature; Yield given. Multistep reaction;
参考文献
Hirama, Masahiro; Uei, Mitsuko
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5307 - 5310
