3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
potassium hydroxide
T=100°C; 0.25 h;
参考文献
Rodriguez-Burruezo, Adrian; Kollmannsberger, Hubert; Prohens, Jaime; Nitz, Siegfried; Nuez, Fernando
Journal of Agricultural and Food Chemistry, 2004 , vol. 52, # 18 p. 5663 - 5669
反应条件
1: 2-methyl-4-hydroxy-1-butene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
T=20°C; 6 h;
2: 4-iodo-2-methyl-but-1-ene in diethyl ether
T=-78 - 20°C; Further stages.;
参考文献
Yong, Kelvin H.; Lotoski, John A.; Chong, J. Michael
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8248 - 8251
反应条件
1: 2-methyl-4-hydroxy-1-butene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
T=20°C; 6 h;
2: TsOCH2CH2CH(CH3)=CH2 in diethyl ether
T=-78 - 20°C;
参考文献
Yong, Kelvin H.; Lotoski, John A.; Chong, J. Michael
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8248 - 8251
反应条件
1: 2-methyl-4-hydroxy-1-butene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
T=20°C; 6 h;
2: 3-methyl-3-butenyl-1-benznesulfonate in diethyl ether
T=-78 - 20°C;
参考文献
Yong, Kelvin H.; Lotoski, John A.; Chong, J. Michael
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8248 - 8251
反应条件
1.1: 84 percent / Ph3P; I2; imidazole / CH2Cl2 / 3 h / 20 °C
2.1: n-BuLi; TMEDA / diethyl ether; hexane / 6 h / 20 °C
2.2: 52 percent / diethyl ether / -78 - 20 °C
View Scheme
参考文献
Yong, Kelvin H.; Lotoski, John A.; Chong, J. Michael
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8248 - 8251
反应条件
1H-imidazole in N,N-dimethyl-formamide
4 h; Ambient temperature;
参考文献
Sueiras; Okamura
Journal of the American Chemical Society, 1980 , vol. 102, # 20 p. 6255 - 6259
反应条件
pyridine
T=0°C; 2.5 h;
参考文献
Piron, Karel; Verniest, Guido; Van Hende, Eva; De Kimpe, Norbert
Arkivoc, 2012 , vol. 2012, # 5 p. 6 - 15
反应条件
method of Brandsma (ref. 9);
参考文献
Atkinson, Robert S.; Grimshire, Michael J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1135 - 1146
反应条件
1: pyridine / CH2Cl2 / 1 h / 20 °C
2: m-CPBA / CH2Cl2 / 0.75 h / 20 °C
3: trifluoroacetic acid / CDCl3
4: acetic acid; sodium acetate; D2O / acetone-d6 / 30 °C / pH 4.75
View Scheme
参考文献
Giner, Jose-Luis; Li, Xiaoyong; Mullins, Joseph J.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10079 - 10086
反应条件
sodium hydride in N,N-dimethyl-formamide
20 h; Ambient temperature;
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
