3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
1: pyridine
2: 15 percent
3: NaH
4: dimethyl copper lithium
5: 1,2-dimethylimidazole / diethyl ether / 3 h / Ambient temperature; Irradiation; without base, other solvents
View Scheme
参考文献
Lombardo, Domenic A.; Weedon, Alan C.
Tetrahedron Letters, 1986 , vol. 27, # 46 p. 5555 - 5558
反应条件
triethylamine in diethyl ether
T=0°C; 1 h;
参考文献
Brodney, Michael A.; Cole, Marcus L.; Freemont, Jamie A.; Kyi, Stella; Junk, Peter C.; Padwa, Albert; Riches, Andrew G.; Ryan, John H.
Tetrahedron Letters, 2007 , vol. 48, # 11 p. 1939 - 1943
反应条件
sodium hydride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
2 h; Heating;
参考文献
Tokuyasu, Takahiro; Kunikawa, Shigeki; McCullough, Kevin J.; Masuyama, Araki; Nojima, Masatomo
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 251 - 260
反应条件
1: pyridine / 0 °C
2: 1) diisopropylamine, butyllithium
3: 97 percent / LiAlH4 / diethyl ether / 0.5 h / Heating
4: 91 percent / PCC, Celite / CH2Cl2 / 2.5 h
View Scheme
参考文献
Little, R. Daniel; Muller, George W.; Venegas, Manuel G.; Caroll, Gary L.; Bukhari, Ahmed; et al.
Tetrahedron, 1981 , vol. 37, # 25 p. 4371 - 4384
反应条件
1: pyridine / 0 °C
2: 1) diisopropylamine, butyllithium
3: 97 percent / LiAlH4 / diethyl ether / 0.5 h / Heating
4: 91 percent / PCC, Celite / CH2Cl2 / 2.5 h
5: 1) butyllithium / 1) THF, 0 deg C, 0.5 h, 2) THF, 0 deg C, 1.5 h
View Scheme
参考文献
Little, R. Daniel; Muller, George W.; Venegas, Manuel G.; Caroll, Gary L.; Bukhari, Ahmed; et al.
Tetrahedron, 1981 , vol. 37, # 25 p. 4371 - 4384
反应条件
1: 1.) TsCl, pyridine; 2.) NaOEt / 1.) ether, 3.5 h, 0 deg C; 2.) EtOH, 2h, reflux
2: 70 percent / H2O2, ammonium molybdate / methanol / 2 h / -15 °C
View Scheme
参考文献
Li, Zhilong; Jung, Heejung; Park, Mira; Lah, Myoung Soo; Koo, Sangho
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1913 - 1917
反应条件
1: 1.) NaH; 2.) BH3, NaOH, H2O2
2: 2.) H(1+)
View Scheme
参考文献
VanMiddlesworth, Frank; Wang, Yi Fong; Zhou, Bing-nan; DiTullio, Dennis; Sih, C. J.
Tetrahedron Letters, 1985 , vol. 26, # 8 p. 961 - 964
反应条件
1: 56 percent / 8 N Jones reagent / acetone / 5 h / Ambient temperature
2: 30 percent / conc. sulfuric acid / acetic acid / 8 h / Heating
3: 1.) KOH / 1.) water, 15 min; 2.) DMF, 24 h, r.t.
4: 58 percent / dimethylaminopyridine / 1 h / Ambient temperature
5: 95 percent / 1.2 N diisobutylaluminiumhydride / hexane; toluene / 1 h / 0 °C
View Scheme
参考文献
Herold; Mohr; Tamm
Helvetica Chimica Acta, 1983 , vol. 66, # 3 p. 744 - 754
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in acetonitrile
T=80 - 81°C; P=760.051 Torr; 24 h; Product distribution / selectivity;
参考文献
Seoul National University Industry Foundation
Patent: US2006/20153 A1, 2006 ;
Location in patent: Page/Page column 11; 12 ;
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in acetonitrile
T=80 - 81°C; P=760.051 Torr; 24 h; Product distribution / selectivity;
参考文献
Seoul National University Industry Foundation
Patent: US2006/20153 A1, 2006 ;
Location in patent: Page/Page column 4; 6 ;
