3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine in acetonitrile
Heck Reaction; 24 h; Reflux;
参考文献
Byung, Hyun Kim; Jong, Gil Lee; Woon, Ki Kim; Young, Gyu Kim
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 814 - 817
反应条件
1: 1.) NaH / 1.) THF, reflux, 2 h; 2.) reflux, 5 h
2: 1.) NaBH4, BF3*Et2O; 2.) Br2, CH3ONa / 1.) THF, 20 deg C, 15 min; 2.) MeOH, 20 deg C, 20 min
View Scheme
参考文献
Suzuki, Shigeaki; Shiono, Manzo; Fujita, Yoshiji
Synthesis, 1983 , # 10 p. 804 - 806
反应条件
1: pyridine / tetrahydrofuran / 3 h / Heating
2: 1.) SnCl4 / 1.) 5 min, 2.) CS2, RT, 17 h
3: 89 percent / SnCl4 / CS2 / 3 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
1: pyridine / tetrahydrofuran / 3 h / Heating
2: 1.) SnCl4 / 1.) 5 min, 2.) CS2, RT, 17 h
3: 89 percent / SnCl4 / CS2 / 3 h / Ambient temperature
4: 57 percent / NaH, 15-crown-5 / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; Inert atmosphereCooling with ice;
参考文献
Chen, Mo; Poulter, C. Dale
Biochemistry, 2010 , vol. 49, # 1 p. 207 - 217
反应条件
in neat (no solvent)
T=225°C; 8 h;
参考文献
Ayer, Stephen W.; Hellou, Jocelyne,; Tischler, Mark; Andersen, Raymond J.
Tetrahedron Letters, 1984 , vol. 25, # 2 p. 141 - 144
反应条件
in neat (no solvent)
T=225°C; 8 h;
参考文献
Ayer, Stephen W.; Hellou, Jocelyne,; Tischler, Mark; Andersen, Raymond J.
Tetrahedron Letters, 1984 , vol. 25, # 2 p. 141 - 144
反应条件
pyridine in dichloromethane
T=0°C; 4 h;
参考文献
Alderdice; Spino; Weiler
Canadian Journal of Chemistry, 1993 , vol. 71, # 11 p. 1955 - 1963
