反应条件
1.1: ethanol; sodium / benzene / 2 h / 0 °C
1.2: 3 h / 50 °C
1.3: 4 h
2.1: hydrogenchloride / ethanol; water / Reflux
3.1: bromine; acetic acid / 1.5 h / Reflux
4.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux
4.2: Cooling with ice
5.1: N,N-dimethyl-formamide / 1.5 h / 20 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
