3-(2-溴苯基)-1H-吡咯合成路线 （共 4 条）
反应条件
sodium hydroxide in ethylene glycol
T=160°C; 2.5 h;
参考文献
Hulcoop, David G.; Lautens, Mark
Organic Letters, 2007 , vol. 9, # 9 p. 1761 - 1764
反应条件
1: 66 percent / sodium hydride / diethyl ether; various solvent(s); dimethylformamide / 3 h
2: 73 percent / NaOH / ethane-1,2-diol / 2.5 h / 160 °C
View Scheme
参考文献
Hulcoop, David G.; Lautens, Mark
Organic Letters, 2007 , vol. 9, # 9 p. 1761 - 1764
反应条件
1: NaOH / methanol; H2O / 18 h / 50 °C
2: 48 percent / etanolamine / 1 h / 170 °C
View Scheme
参考文献
Sakai; Suzuki; Nunami; Yoneda; Onoda; Iwasawa
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 8 p. 2384 - 2393
反应条件
1: 60 percent / NaH (65percent in oil) / tetrahydrofuran / 3 h / 40 - 50 °C
2: NaOH / methanol; H2O / 18 h / 50 °C
3: 48 percent / etanolamine / 1 h / 170 °C
View Scheme
参考文献
Sakai; Suzuki; Nunami; Yoneda; Onoda; Iwasawa
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 8 p. 2384 - 2393
