2-氟-5-[(3-氧代-1(3H)-异苯并呋喃亚基)甲基]苯腈合成路线 （共 7 条）
反应条件
triethylamine in tetrahydrofuran T=15 - 20°C;
参考文献
WO2012/71684 A1, ;
Page/Page column 23 ;
WO 2012/071684 A1
反应条件
triethylamine in 2-methyl tetrahydrofuran T=20°C;
参考文献
WO2008/47082 A2, ;
Page/Page column 27 ;
WO 2008/047082 A2
反应条件
1: sodium; methanol / 0.5 h / 0 - 20 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 15 - 20 °C View Scheme
参考文献
WO2012/71684 A1, ;
WO 2012/071684 A1
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 24 h / 170 °C 1.2: celite / 1 h / 80 °C 2.1: triethylamine / tetrahydrofuran / 15 - 20 °C View Scheme
参考文献
WO2012/71684 A1, ;
WO 2012/071684 A1
反应条件
1: With water; sodium hydroxide T=90°C; 1 h; 2: With hydrazine hydrate in water T=70°C; 3: With hydrogenchloride in water T=20°C; pH=3 - 4;
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;
反应条件
1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With sodium hydroxide
Reflux;
2: With NH2NH2•xH2O
3: N-(tert-butyl-oxycarbonyl)-homopiperazine
参考文献
THE JOHNS HOPKINS UNIVERSITY; KERN, Scott; GHOSH, Soma
Patent: WO2014/78633 A1, 2014 ;
Location in patent: Paragraph 0078 ;
反应条件
1.1: sodium hydroxide; water / 1 h / 90 °C
1.2: 70 °C
1.3: 20 °C / pH 3 - 4
2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C
View Scheme
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;
