LATRUNCULIN B合成路线 （共 36 条）
反应条件
2: 81 percent / KN(SiMe3)2 / tetrahydrofuran / 0 °C 3: 98 percent / pyridine, (HF)x / tetrahydrofuran 4: 68 percent / DEAD, PH3P / benzene 5: 68 percent / Ce(NH4)2(NO3)6 / H2O; acetonitrile 6: HOAc / tetrahydrofuran; H2O / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 108, # 9 p. 2451 - 2453
反应条件
Grubb's 2nd generation catalyst in dichloromethane T=40°C; ring closing metathesis; 7 h; optical yield given as percent de;
参考文献
Tetrahedron Letters, , vol. 50, # 3 p. 298 - 301
反应条件
1: 75 percent / Ba(OH)2*8H2O / tetrahydrofuran; H2O / 3 h 2: 57 percent / aq. HCl / tetrahydrofuran / 20 °C 3: 92 percent / camphor-10-sulfonic acid / 20 °C 4: pyridine / CH2Cl2 / 1 h / -20 °C 5: 45 mg / [15]crown-5 ether / tetrahydrofuran / 20 °C 6: 70 percent / Mo[N-(tBu)(3,5-dimethylphenyl)]3 / toluene / 20 h / 80 °C 7: 100 percent / hydrogen / Lindlar / CH2Cl2 8: 78 percent / aq. cerium ammonium nitrate / acetonitrile / 3 h View Scheme
参考文献
Chemistry - A European Journal, , vol. 13, # 1 p. 115 - 134
反应条件
1: 57 percent / aq. HCl / tetrahydrofuran / 20 °C 2: 92 percent / camphor-10-sulfonic acid / 20 °C 3: pyridine / CH2Cl2 / 1 h / -20 °C 4: 45 mg / [15]crown-5 ether / tetrahydrofuran / 20 °C 5: 70 percent / Mo[N-(tBu)(3,5-dimethylphenyl)]3 / toluene / 20 h / 80 °C 6: 100 percent / hydrogen / Lindlar / CH2Cl2 7: 78 percent / aq. cerium ammonium nitrate / acetonitrile / 3 h View Scheme
参考文献
Chemistry - A European Journal, , vol. 13, # 1 p. 115 - 134
反应条件
1: 92 percent / camphor-10-sulfonic acid / 20 °C 2: pyridine / CH2Cl2 / 1 h / -20 °C 3: 45 mg / [15]crown-5 ether / tetrahydrofuran / 20 °C 4: 70 percent / Mo[N-(tBu)(3,5-dimethylphenyl)]3 / toluene / 20 h / 80 °C 5: 100 percent / hydrogen / Lindlar / CH2Cl2 6: 78 percent / aq. cerium ammonium nitrate / acetonitrile / 3 h View Scheme
参考文献
Chemistry - A European Journal, , vol. 13, # 1 p. 115 - 134
反应条件
sodium tetrahydroborate in methanol
2 h; Ambient temperature;
参考文献
Kashman; Groweiss; Lidor; et al.
Tetrahedron, 1985 , vol. 41, # 10 p. 1905 - 1914
