Boc-D-2.3-二氨基丙酸合成路线 （共 20 条）
反应条件
[bis(acetoxy)iodo]benzene in water; ethyl acetate; acetonitrile T=16 - 20°C;
参考文献
Mitra, Roopa; Ganesh, Krishna N.
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5696 - 5704
反应条件
ammonia in tetrahydrofuran T=0°C; 1 h;
参考文献
Arnold; Kalantar; Vederas
Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 7105 - 7109
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr;
参考文献
Journal of the American Chemical Society, , vol. 133, # 7 p. 2076 - 2079
反应条件
hydrogen; palladium on activated charcoal in methanol 24 h; Yield given;
参考文献
Tetrahedron, , vol. 50, # 17 p. 5049 - 5066
反应条件
1: 93 percent / 1-ethyl-3-<3-(dimethylamino)propyl>-carbodiimide / CH2Cl2 / 15 h / Ambient temperature 2: 1.) sodium iodide, 2.) 60percent sodium hydride in mineral oil / 1.) dimethylformamide, 0 deg C, 30 min, 2.) dimethylformamide, 0 deg C, 15 min; room temperature, 90 min 3: hydrogen / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 17 p. 5049 - 5066
反应条件
1: 1.) sodium iodide, 2.) 60percent sodium hydride in mineral oil / 1.) dimethylformamide, 0 deg C, 30 min, 2.) dimethylformamide, 0 deg C, 15 min; room temperature, 90 min 2: hydrogen / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 17 p. 5049 - 5066
反应条件
potassium hydroxide; potassium carbonate in tetrahydrofuran; water
参考文献
More, Swati S.; Vince, Robert
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4650 - 4656
反应条件
sodium carbonate in 1,4-dioxane; water T=25°C; 3 h;
参考文献
Cephalon, Inc.
Patent: US2006/189806 A1, 2006 ;
Location in patent: Page/Page column 44 ;
参考文献
Miyazaki, Anna; Fujisawa, Yutaka; Shiotani, Kimitaka; Fujita, Yoshio; Li, Tingyou; Tsuda, Yuko; Yokoi, Toshio; Bryant, Sharon D.; Lazarus, Lawrence H.; Okada, Yoshio
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 9 p. 1152 - 1158
反应条件
in methanol; diethyl ether; dichloromethane T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/93414 A1, 2007 ;
Location in patent: Page/Page column 55 ;
