1-(1,2-二氧代丙基)-s-脯氨酸合成路线 （共 6 条）
反应条件
hydrogenchloride; nitrogen; hydroxylamine hydrochloride; sodium acetate; palladium hydroxide-on-carbon in ethanol; water
参考文献
Celgene Corporation
Patent: US5424454 A1, 1995 ;
反应条件
nitrogen; palladium in ethanol
参考文献
Celgene Corporation
Patent: US5424454 A1, 1995 ;
反应条件
hydrogen; palladium in tetrahydrofuran; ethanol
6 h;
参考文献
Krit, N. A.; Gracheva, I. N.; Filatova, M. P.; Reissmann, S.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 7 p. 482 - 485
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 7 p. 44 - 46
反应条件
sodium methylate in 1,4-dioxane
参考文献
DSM Chemie Linz GmbH
Patent: US5898076 A1, 1999 ;
反应条件
sodium cyanoborohydride; sodium hydrogencarbonate; silica gel in ethanol; water
参考文献
Ryan; James W.; Chung; Alfred
Patent: US4766110 A1, 1988 ;
反应条件
1: 36 percent / 1-hydroxybenzotriazole, DCC, diisopropylethylamine / CH2Cl2 / 32 h / Ambient temperature
2: 72 percent / H2 / Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Jou, Gemma; Gonzalez, Isabel; Albericio, Fernando; Lloyd-Williams, Paul; Giralt, Ernest
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 354 - 366
