2-氨基-1H-苯并咪唑-5-羧酸合成路线 （共 4 条）
反应条件
1: in water; acetonitrile
T=20°C;
2: With ammonia in water; ethyl acetate; acetonitrile
3: With hydrogenchloride in water
Reflux;
参考文献
PFIZER INC.
Patent: US2012/270893 A1, 2012 ;
Location in patent: Page/Page column 27 ;
参考文献
Dellweg et al.
Biochemische Zeitschrift, 1956 , vol. 327, p. 422,447
反应条件
ammonium hydroxide
T=60°C; 18 h;
参考文献
Nakayama; Taira; Ikeda; Ashizawa; Oda; Arakawa; Fujii
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 117 - 125
反应条件
1: 81.8 percent / NaHCO3 / dimethylformamide / 2 h / 70 °C
2: aq. NH4OH / 18 h / 60 °C
View Scheme
参考文献
Nakayama; Taira; Ikeda; Ashizawa; Oda; Arakawa; Fujii
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 117 - 125
