D-赤式-二氢-D-鞘氨醇合成路线 （共 64 条）
反应条件
1: 85 percent / BuONO, H2SO4 / diethyl ether / 15 h / 20 °C 2: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C 3: 99 percent / NaBH4 / ethanol / 1 h / 20 °C 4: 85 percent / imidazole / dimethylformamide / 24 h / 20 °C 5: 99 percent / (COCl)2, DMSO / CH2Cl2 / 0.25 h / -78 °C 6: 1.) chiral amino alcohol derived from (-)-α-pinene, BH3*PhNEt2, BH3*Me2S; 2.) HCl / 1.) THF, reflux, 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 29 p. 5199 - 5200
反应条件
1: 52 percent / MgCl2, Et3N / acetonitrile / 18 h / 20 °C 2: 85 percent / BuONO, H2SO4 / diethyl ether / 15 h / 20 °C 3: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C 4: 99 percent / NaBH4 / ethanol / 1 h / 20 °C 5: 85 percent / imidazole / dimethylformamide / 24 h / 20 °C 6: 99 percent / (COCl)2, DMSO / CH2Cl2 / 0.25 h / -78 °C 7: 1.) chiral amino alcohol derived from (-)-α-pinene, BH3*PhNEt2, BH3*Me2S; 2.) HCl / 1.) THF, reflux, 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 29 p. 5199 - 5200
反应条件
sulfuric acid in methanol Heating;
参考文献
Helvetica Chimica Acta, , vol. 43, p. 2198 - 2201
反应条件
1: diethyl ether / 1.) -78 deg C, 2 h, 2.) -45 deg C, 30 min 2: 196 mg / 1M HCl / methanol / 3 h / Heating 3: 81 percent / aq. hydrazine, ethanol / 1.5 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 53, # 6 p. 1783 - 1784
反应条件
1: 196 mg / 1M HCl / methanol / 3 h / Heating 2: 81 percent / aq. hydrazine, ethanol / 1.5 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 53, # 6 p. 1783 - 1784
参考文献
Zhurnal Organicheskoi Khimii, , vol. 6, # 4 p. 665 - 668,668 - 670
反应条件
1.1: acetonitrile / |Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere 2.2: -78 - 20 °C / |Inert atmosphere 3.1: hydrogenchloride; palladium on carbon; hydrogen / ethyl acetate / 48 h / 320 °C View Scheme
参考文献
Arkivoc, , vol. 2012, # 6 p. 421 - 436
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: hydrogenchloride; palladium on carbon; hydrogen / ethyl acetate / 48 h / 320 °C View Scheme
参考文献
Arkivoc, , vol. 2012, # 6 p. 421 - 436
反应条件
lithium hydroxide; ammonia; sodium; sodium hydride Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 50, # 20 p. 3752 - 3757
反应条件
Gewinnung mit Hilfe von L-Mandelsaeure;
参考文献
Chem.Physics Lipids, , vol. 8, p. 10,21
