反应条件
1: 67 percent / Et3N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2 / 0 - 20 °C
2: 85 percent / NaBr; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; aq. NaOCl / NaHCO3 / toluene; ethyl acetate / 1.25 h / -5 - 0 °C
View Scheme
参考文献
Kokotos, George; Six, David A.; Loukas, Vassilios; Smith, Timothy; Constantinou-Kokotou, Violetta; Hadjipavlou-Litina, Dimitra; Kotsovolou, Stavroula; Chiou, Antonia; Beltzner, Christopher C.; Dennis, Edward A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3615 - 3628