反应条件
1: 1) tetrabutylammonium fluoride, 2) (PhO)3PMe+I- / 1) HMPA, 5 h, 2) DMF, 12 h,
2: 1) t-butyllithium, CuBr*SMe2 / 1) Et2O, -35 deg C, 5 min, 2) -78 deg C, 0.5 h, then 0 deg C, 1 h
3: 1) DIBAL-H, 2) KH / 1) -78 deg C, THF, 1 h, then 6 h, room temperature, 2) -78 deg C, warming up to room temperature over 1 h, then 1 h, room temperature
View Scheme
参考文献
Barrett, Anthony G. M.; Flygare, John A.
Journal of Organic Chemistry, 1991 , vol. 56, # 2 p. 638 - 642
