反应条件
1: 1H-imidazole / dichloromethane / 3 h / 20 °C / |Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; lithium tert-butylate / 1,4-dioxane / 110 °C / |Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme
参考文献
CRYSTAL PHARMA, S.A.U.; Perez Encabo, Alfonso; Turiel Hernandez, Jose Angel; Gallo Nieto, Francisco Javier; Lorente Bonde-Larsen, Antonio; Sandoval Rodriguez, Celso Miguel
Patent: US2014/11992 A1, 2014 ;