in water T=20°C; 8.5 h; Kluyvera citrophila KY-7844, phosphate buffer (pH 6.75);

1: 77 percent / O3, H2O2 / CH2Cl2; methanol 2: carbonyl diimidazole / tetrahydrofuran 3: 85 percent / p-dodecyl-SO2N3, TEA / acetonitrile 4: 72 percent / Rh2(O2CC7H15)4 / CH2Cl2 5: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 6: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 1.) Li/NH3, t-BuOH 2.) aq. NaHCO3 / 1.) THF 2.) CH3CN 2: 77 percent / O3, H2O2 / CH2Cl2; methanol 3: carbonyl diimidazole / tetrahydrofuran 4: 85 percent / p-dodecyl-SO2N3, TEA / acetonitrile 5: 72 percent / Rh2(O2CC7H15)4 / CH2Cl2 6: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 7: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 2: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: carbonyl diimidazole / tetrahydrofuran 2: 85 percent / p-dodecyl-SO2N3, TEA / acetonitrile 3: 72 percent / Rh2(O2CC7H15)4 / CH2Cl2 4: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 5: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 72 percent / Rh2(O2CC7H15)4 / CH2Cl2 2: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 3: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 85 percent / p-dodecyl-SO2N3, TEA / acetonitrile 2: 72 percent / Rh2(O2CC7H15)4 / CH2Cl2 3: 72 percent / (PhO)3PCl2, HCl / pyridine; CH2Cl2; ethyl acetate; various solvent(s) 4: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 1.) TEA 2.) TEA, i-BuOCOCl / 2.) DMBA / 1.) ETOH, H2O 2.) DMF View Scheme

1: 77.5 percent / piperazine / CHCl3 / 3 h 2: 1.) m-chloroperbenzoic acid, 2.) SO2Cl2 / 1.) CHCl3, 0 deg C, 30 min, 2.) CH2Cl2, 0 deg C, 1 h 3: 71.8 percent / trifluoroacetic acid / 1 h / 0 °C 4: hydrazine hydrate, 0.2N NaOH / 5 deg C, 3 h, 35 deg C 5: 78.2 percent / H2O / 8.5 h / 20 °C / Kluyvera citrophila KY-7844, phosphate buffer (pH 6.75) View Scheme