反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 20 min
2: 1.) DIBAL, 2.) MeLi / 1.) toluene, Et2O, 0 deg C to reflux, 1 h, 2.) toluene, Et2O, 0 deg C
3: 70 percent / VO(acac)2, t-BuOOH / CH2Cl2; H2O / 2 h / Ambient temperature
4: 89 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C
5: 59 percent / tetrahydrofuran / 1.5 h / 0 - 20 °C
View Scheme
参考文献
Shipman, Michael; Thorpe, Heidi R.; Clemens, Ian R.
Tetrahedron, 1998 , vol. 54, # 47 p. 14265 - 14282
