2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
1: triethylamine; benzene
2: 1.) m-chloroperoxybenzoic acid / 2.) 40 deg C
View Scheme
参考文献
Eaton, Philip E.; Bunnelle, William H.
Tetrahedron Letters, 1984 , vol. 25, # 1 p. 23 - 26
反应条件
in benzene
T=25°C; 9 h;
参考文献
Schulz, Manfred; Meske, Michael; Kluge, Ralph
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 4 p. 350 - 354
参考文献
Volpe, Tony; Revial, Gilbert; Pfau, Michel; d'Angelo, Jean
Tetrahedron Letters, 1986 , vol. 27, # 25 p. 2853 - 2854
反应条件
triethylamine; dibromotriphenyl-phosphorane in benzene
4 h; Ambient temperature;
参考文献
Piers, Edward; Grierson, John R.; Lau, Cheuk Kun; Nagakura, Isao
Canadian Journal of Chemistry, 1982 , vol. 60, p. 210 - 223
反应条件
iodine; triethylamine; triphenylphosphine in acetonitrile
T=80 - 90°C; 6 h;
参考文献
Tietze, Lutz F.; Vock, Carsten A.; Krimmelbein, Ilsa K.; Wiegand, J. Matthias; Nacke, Linda; Ramachandar, Tokala; Islam, Kazi M. D.; Gatz, Christiane
Chemistry - A European Journal, 2008 , vol. 14, # 12 p. 3670 - 3679
反应条件
1: 60 percent / HOAc / xylene / 7 h / Heating
2: 80 percent / H2 / 10percent Pd-C / ethanol / 0.25 h / 775.7 Torr
3: 35 percent / TosOH / benzene / 2 h / Heating
View Scheme
参考文献
Bindra,J.S. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 921 - 925
反应条件
1: 76.5 percent / toluene
2: 2.) water / 1.) THF, diethyl ether, room temperature, overnight, 2.) diethyl ether, THF
View Scheme
参考文献
Shawe, Thomas T.; Hansen, Darren B.; Peet, Kelly Ann; Prokopowicz, Anthony S.; Robinson, Patrice M.; Cannon, Annatina; Dougherty, Kathleen E.; Ross, Andrew A.; Landino, Linda M.
Tetrahedron, 1997 , vol. 53, # 5 p. 1547 - 1556
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; 10 h; also with other solvents; Yield given. Yields of byproduct given;
参考文献
Schick, Hans; Schwarz, Hartmut; Finger, Angelika; Schwarz, Sigfrid
Tetrahedron, 1982 , vol. 38, # 9 p. 1279 - 1283
反应条件
1: With potassium hydroxide in 1,4-dioxane; water
Heating / reflux;
2: With hydrogenchloride in water
T=120°C; 0.25 h;
参考文献
Allergan, Inc.
Patent: US2004/157901 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
hydrogenchloride; potassium hydroxide; sodium hydrogencarbonate; methyl iodide in 1,4-dioxane; water
参考文献
Allergan, Inc.
Patent: US2004/235958 A1, 2004 ;
Title/Abstract Full Text Show Details
ALLERGAN, INC.
Patent: US2005/164992 A1, 2005 ;
