2-甲基-1,3-环戊二酮合成路线 （共 110 条）
参考文献
Yan, Jun; Travis, Benjamin R.; Borhan, Babak
Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9299 - 9302
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide T=15 - 25°C; 6 h; 2: methyl vinyl ketone in dimethyl sulfoxide T=15 - 25°C; asymmetric Robinson annulation; 145 h; Title compound not separated from byproducts;
参考文献
Rajagopal; Narayanan; Swaminathan
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4887 - 4890
反应条件
1: acetic acid / water / 16 h / 70 °C 2: L-proline / N,N-dimethyl-formamide / 16 h / 20 °C View Scheme
参考文献
Sauvee, Claire; Schaefer, Anja; Sunden, Henrik; Ma, Jian-Nong; Gustavsson, Anna-Lena; Burstein, Ethan S.; Olsson, Roger
MedChemComm, 2013 , vol. 4, # 11 p. 1439 - 1442
反应条件
1: triethylamine / dichloromethane / 12 h 2: acetic acid / water / 48 h / 20 °C View Scheme
参考文献
Pedrosa, Rafael; Andres, Jose Maria; Manzano, Ruben; Perez-Lopez, Cesar
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3101 - 3104
反应条件
1: 60 percent / 40percent methanol. Triton-B, t-butanol / xylene / 6 h / Heating 2: 60 percent / p-toluenesulfonic acid / benzene / 10 h / Ambient temperature 3: 95 percent / NaBH4 / methanol; tetrahydrofuran / 2 h / Ambient temperature 4: 60 percent / H2 / 10percent Pd/C View Scheme
参考文献
Ramesh Babu; Ramana; Ramadas
Steroids, 1990 , vol. 55, # 3 p. 101 - 104
反应条件
1: With acetic acid in water 2: With R-(+)-proline in N,N-dimethyl-formamide 3: With sulfuric acid in N,N-dimethyl-formamide Further stages.;
参考文献
Molander, Gary A.; Quirmbach, Michael S.; Silva Jr., Luiz F.; Spencer, Keith C.; Balsells, Jaume
Organic Letters, 2001 , vol. 3, # 15 p. 2257 - 2260
反应条件
1: 100 percent / triethylamine / acetonitrile / 20 °C 2: (S)-5,6-dimethyl-2-(pyrrolidin-2-yl)-1H-benzimidazole; TFA / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Sevillano; Melero; Caballero; Tome; Lelievre; Geering; Crambert; Carron; Medarde; San Feliciano
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 127 - 136
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide T=15 - 25°C; 6 h; 2: methyl vinyl ketone in dimethyl sulfoxide T=15 - 25°C; asymmetric Robinson annulation; 145 h; 3: With pyridinium p-toluenesulfonate in benzene 2 h; Heating;
参考文献
Rajagopal; Narayanan; Swaminathan
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4887 - 4890
反应条件
1: triethylamine / dichloromethane / 12 h 2: 4-nitro-benzoic acid; (S)-N-(2-(4-methylphenylsulfonamido)ethyl)pyrrolidine-2-carboxamide / acetonitrile / 96 h / -18 °C View Scheme
参考文献
Pedrosa, Rafael; Andres, Jose Maria; Manzano, Ruben; Perez-Lopez, Cesar
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3101 - 3104
参考文献
Journal of Organic Chemistry, , vol. 69, # 26 p. 9299 - 9302
