2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in methanol Heating;
参考文献
Trost; Curran
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5699 - 5700
反应条件
sodium hydroxide 24 h;
参考文献
Brooks, Dee W.; Mazdiyasni, Hormoz; Grothaus, Paul G.
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3223 - 3232
反应条件
Ru(Cp*)(η3-C3H5)(p-CH3C6H5SO3)2 in dichloromethane; acetonitrile T=50°C; 3 h; regioselective reaction;
参考文献
Gruber, Stefan; Pregosin, Paul S.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 18 p. 3235 - 3242
反应条件
sodium hydroxide; sodium bromide in water T=60°C; 10 h;
参考文献
Schick, Hans; Schwarz, Hartmut; Finger, Angelika; Schwarz, Sigfrid
Tetrahedron, 1982 , vol. 38, # 9 p. 1279 - 1283
反应条件
palladium diacetate; triphenylphosphine in tetrahydrofuran 6 h; Ambient temperature;
参考文献
Mandai; Kaihara; Tsuji
Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 5847 - 5849
反应条件
potassium carbonate in water T=70°C; 10 h; also with further solvent; Yield given. Yields of byproduct given;
参考文献
Nayyar, Sandeep; Trehan, Inderraj; Kaur, Jasamrit
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2342 - 2345
反应条件
1: 100 percent / triethylamine / acetonitrile / 20 °C 2: (S)-5,6-dimethyl-2-(pyrrolidin-2-yl)-1H-benzimidazole; TFA / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 1 p. 167 - 177
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide T=15 - 25°C; 6 h; 2: methyl vinyl ketone in dimethyl sulfoxide T=15 - 25°C; asymmetric Robinson annulation; 145 h; 3: With pyridinium p-toluenesulfonate in benzene 2 h; Heating;
参考文献
Tetrahedron Letters, , vol. 42, # 29 p. 4887 - 4890
反应条件
1: triethylamine / dichloromethane / 12 h 2: 4-nitro-benzoic acid; (S)-N-(2-(4-methylphenylsulfonamido)ethyl)pyrrolidine-2-carboxamide / acetonitrile / 96 h / -18 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3101 - 3104
反应条件
1: triethylamine / dichloromethane / 12 h 2: acetic acid / water / 48 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3101 - 3104
