2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
triethylamine in ethyl acetate
6 h; Heating;
参考文献
Jayaraman, S.; Rajagopalan, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 125 - 127
反应条件
1: With acetic acid in water
2: With R-(+)-proline in N,N-dimethyl-formamide
3: With sulfuric acid in N,N-dimethyl-formamide
Further stages.;
参考文献
Molander, Gary A.; Quirmbach, Michael S.; Silva Jr., Luiz F.; Spencer, Keith C.; Balsells, Jaume
Organic Letters, 2001 , vol. 3, # 15 p. 2257 - 2260
反应条件
1: 100 percent / triethylamine / acetonitrile / 20 °C
2: (S)-5,6-dimethyl-2-(pyrrolidin-2-yl)-1H-benzimidazole; TFA / tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Sevillano; Melero; Caballero; Tome; Lelievre; Geering; Crambert; Carron; Medarde; San Feliciano
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 127 - 136
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide
T=15 - 25°C; 6 h;
2: methyl vinyl ketone in dimethyl sulfoxide
T=15 - 25°C; asymmetric Robinson annulation; 145 h;
3: With pyridinium p-toluenesulfonate in benzene
2 h; Heating;
参考文献
Rajagopal; Narayanan; Swaminathan
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4887 - 4890
反应条件
1: triethylamine / dichloromethane / 12 h
2: 4-nitro-benzoic acid; (S)-N-(2-(4-methylphenylsulfonamido)ethyl)pyrrolidine-2-carboxamide / acetonitrile / 96 h / -18 °C
View Scheme
参考文献
Pedrosa, Rafael; Andres, Jose Maria; Manzano, Ruben; Perez-Lopez, Cesar
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3101 - 3104
反应条件
sodium hydride; triphenylphosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) in dimethyl sulfoxide
T=65°C; 72 h;
参考文献
Gauthier, Veronique; Gazes, Bernard; Gore, Jacques
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 6 p. 563 - 579
参考文献
Demir, Ayhan S.; Enders, Dieter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1989 , vol. 44, # 7 p. 834 - 838
反应条件
1: triethylamine / 120 h / 40 °C / 8a(enone) was alkylated in situ
2: H3PO4, P2O5 / benzene / 0.75 h / Heating
View Scheme
参考文献
Douglas,G.H. et al.
Journal of the Chemical Society, 1963 , p. 5072 - 5094
反应条件
toluene-4-sulfonic acid in toluene
48 h; Heating;
参考文献
Banerjee, Ajoy K.; Vera, William
Recueil des Travaux Chimiques des Pays-Bas, 1995 , vol. 114, # 3 p. 87 - 90
反应条件
1: DABCO / 1,2-dimethoxy-ethane / Ambient temperature
2: p-TsOH / toluene / Heating
View Scheme
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, R.; FRYE, Leah, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2013/58809 A1, 2013 ;
