2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
potassium hydroxide in methanol
参考文献
Swaminathan,S. et al.
Tetrahedron, 1970 , vol. 26, p. 1453 - 1461
反应条件
(i) benzene-1,4-diol, Py, xylene, (ii) TsOH; Multistep reaction;
参考文献
Banerjee,D.K. et al.
Synthesis, 1976 , p. 307 - 308
反应条件
in triethylamine; benzene
参考文献
Eaton, Philip E.; Bunnelle, William H.
Tetrahedron Letters, 1984 , vol. 25, # 1 p. 23 - 26
反应条件
(i) NaH, THF, (ii) /BRN= 774156/; Multistep reaction;
参考文献
de Groot,A.; Jansen,B.J.M.
Recueil des Travaux Chimiques des Pays-Bas, 1979 , vol. 98, p. 487 - 492
反应条件
N-benzyl-trimethylammonium hydroxide in benzene
Ambient temperature;
参考文献
Ramadas, S. R.; Chenchaiah, P. Ch.; Rao, J. Appa; Kumareasan, S.
Tetrahedron Letters, 1983 , vol. 24, # 48 p. 5403 - 5406
反应条件
1: Ph3P, DBU / PdCl2 / tetrahydrofuran / 18 h / Heating
2: 1percent aq. H2SO4 / dioxane / 2 h / 60 °C
View Scheme
参考文献
Yoshida, Jun-ichi; Nakatani, Shogo; Sakaguchi, Kazuhiko; Isoe, Sachihiko
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3383 - 3389
反应条件
potassium fluoride in xylene
T=120°C; 1 h;
参考文献
Yanami, Tetsuji; Ballatore, Annie; Miyashita, Masaaki; Kato, Michiharu; Yoshikoshi, Akira
Synthesis, 1980 , # 5 p. 407 - 409
反应条件
1: 1.) n-butyl-lithium / 1.) hexane, hexamethylphosphoramide, THF, -78 deg C, 20 min, 2.) -78 deg C, 1 h
2: sodium acetate / 24 h / 25 °C
View Scheme
参考文献
Barker, Andrew J.; Pattenden, Gerald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1885 - 1891
反应条件
1: 1.) n-butyl-lithium / 1.) hexane, hexamethylphosphoramide, THF, -78 deg C, 20 min, 2.) -78 deg C, 1 h
2: sodium acetate / 24 h / 25 °C
View Scheme
参考文献
Barker, Andrew J.; Pattenden, Gerald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1885 - 1891
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C
2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C
3: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
4: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
