2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
sodium hydrogencarbonate in water
参考文献
Geetha, G.; Raju, N.; Rajagopalan, K.; Swaminathan, S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 3 p. 238 - 239
反应条件
sodium hydroxide in water
T=60°C; 7 h; Yields of byproduct given;
参考文献
Schick, Hans; Schwarz, Hartmut; Finger, Angelika; Schwarz, Sigfrid
Tetrahedron, 1982 , vol. 38, # 9 p. 1279 - 1283
反应条件
1: 96 percent / TsOH / benzene / Heating
2: 78 percent / nBuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / -100 °C
3: 1) MeI, 2) 6 N HCl / 1) 60 deg C, 2) r.t., 5 min
View Scheme
参考文献
Demir, Ayhan S.; Enders, Dieter
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 6 p. 553 - 563
反应条件
1: 94 percent / triethylamine / ethyl acetate / 36 h / Ambient temperature
2: 75 percent / methanesulfonic acid / CH2Cl2 / 0.25 h / 0 °C
3: 25 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / benzene / 4 h / Heating
4: 66 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature
5: 58 percent / NaI, trimethylchlorosilane / 70 °C
View Scheme
参考文献
Ikegawa, Shigeo; Kurosawa, Takao; Tohma, Masahiko
Steroids, 1990 , vol. 55, # 6 p. 250 - 255
反应条件
1: pTSA monohydrate / toluene / 16 h / Heating
2: 1,3,5-trimethyl-benzene / 9 h / Heating
View Scheme
参考文献
Trost; McDougal; Haller
Journal of the American Chemical Society, 1984 , vol. 106, # 2 p. 383 - 395
反应条件
toluene-4-sulfonic acid
1.) toluene, 2.) mesitylene, reflux, 9 h; Yield given. Multistep reaction;
参考文献
Trost; McDougal
Journal of the American Chemical Society, 1982 , vol. 104, # 22 p. 6110 - 6112
反应条件
1: 95 percent / H2O; diethyl ether / 6 h
2: 75 percent / conc. HCl / methanol / 0.75 h / Ambient temperature
View Scheme
参考文献
Krishna, M. Vijaya; Ramadas, S.R.
Heterocycles, 1981 , vol. 16, # 3 p. 405 - 409
反应条件
pyridinium p-toluenesulfonate in neat (no solvent)
T=200°C; 0.25 h;
参考文献
Coates, Robert M.; Hobbs, Steven J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 140 - 152
参考文献
Coates, Robert M.; Hobbs, Steven J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 140 - 152
反应条件
1: KH, 18-crown-6 / tetrahydrofuran / Heating
2: camphorsulfonic acid
3: LiAlH4 / tetrahydrofuran / Heating
4: pyridine
5: 10percent HCl / acetic acid
View Scheme
参考文献
Ohnuma, Takeshi; Tabe, Masayasu; Shiiya, Keiko; Ban, Yoshio
Tetrahedron Letters, 1983 , vol. 24, # 39 p. 4249 - 4252
