4-氨基-1-{5-O-[二(4-甲氧基苯基)(苯基)甲基]-2-脱氧呋喃戊糖基}-2(1H)-嘧啶酮合成路线 （共 24 条）
反应条件
hexafluoroisopropyl alcohol 3 h; Ambient temperature;
参考文献
Leonard, Nelson J.; Neelima
Tetrahedron Letters, 1995 , vol. 36, # 43 p. 7833 - 7836
反应条件
ammonium hydroxide in 1,4-dioxane
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23382 A1, 2004 ;
Location in patent: Page/Page column 17 ;
反应条件
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Etherification; 2 h;
参考文献
Kataoka, Masanori; Hayakawa, Yoshihiro
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6087 - 6089
反应条件
pyridine; dichloro-acetic acid; triethylamine
T=25°C; 1.5 h;
参考文献
Hayakawa, Yoshihiro; Kataoka, Masanori
Journal of the American Chemical Society, 1998 , vol. 120, # 48 p. 12395 - 12401
反应条件
methyl(diphenyl)-phosphine in 1,4-dioxane; water
T=20°C; 0.333333 h;
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
N-butylamine in 1,4-dioxane; methanol
T=37°C; 15 h;
参考文献
McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H.
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
反应条件
1: 80 percent / pyridine / 2.5 h / 20 °C
2: 94 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1: pyridine / 1.5 h
2: n-butylamine / methanol; dioxane / 15 h / 37 °C
View Scheme
参考文献
McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H.
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
反应条件
in 1,4-dioxane; methanol
T=37°C; 24 h; Yields of byproduct given;
参考文献
McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H.
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
反应条件
in 1,4-dioxane; methanol
T=37°C; 24 h; Yields of byproduct given;
参考文献
McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H.
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
