4-氨基-1-{5-O-[二(4-甲氧基苯基)(苯基)甲基]-2-脱氧呋喃戊糖基}-2(1H)-嘧啶酮合成路线 （共 24 条）
反应条件
in 1,4-dioxane; methanol
T=37°C; 2 h; Yields of byproduct given;
参考文献
McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H.
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine; triethylamine
3 h;
参考文献
Ti, G. S.; Gaffney, B. L.; Jones, R. A.
Journal of the American Chemical Society, 1982 , vol. 104, # 5 p. 1316 - 1319
反应条件
1: With 1H-1,2,4-triazol; triethylamine; trichlorophosphate
T=-15 - 0°C;
2: With ammonia in 1,4-dioxane; water
T=20°C;
参考文献
Divakar, Kikkeri J.; Sawant, Chitra M.; Mulla; Zemse, Deepak V.; Sitabkhan, Sakina M.; Ross, Bruce S.; Sanghvi, Yogesh S.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1321 - 1325
反应条件
1: pyridine / 3 h / 20 °C
2: 80 percent / pyridine / 2.5 h / 20 °C
3: 94 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1: pyridine / 0.33 h / 20 °C
2: pyridine / 3 h / 20 °C
3: 80 percent / pyridine / 2.5 h / 20 °C
4: 94 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
in N,N-dimethyl-formamide
T=60°C; 16 h;
参考文献
Abramova; Vasil'eva; Ivanova; Shishkin; Sil'nikov
Russian Journal of Bioorganic Chemistry, 2004 , vol. 30, # 3 p. 224 - 233
反应条件
1: triethylamine / acetonitrile / 0 - 5 °C
2: POCl3; N-methylpyrrolidine / acetonitrile
3: NH3 / H2O; dioxane / 20 °C
View Scheme
参考文献
Divakar, Kikkeri J.; Sawant, Chitra M.; Mulla; Zemse, Deepak V.; Sitabkhan, Sakina M.; Ross, Bruce S.; Sanghvi, Yogesh S.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1321 - 1325
反应条件
1: 80 percent / pyridine / 2.5 h / 20 °C
2: 94 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
0.00277778 h;
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
反应条件
1: 61 percent / 4-(dimethylamino)pyridine (DMAP), pyridine, 4 Angstroem MS / 2 h
2: 1M DBU / acetonitrile / 0 h
View Scheme
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
