4-氨基-1-{5-O-[二(4-甲氧基苯基)(苯基)甲基]-2-脱氧呋喃戊糖基}-2(1H)-嘧啶酮合成路线 （共 24 条）
反应条件
1: POCl3; N-methylpyrrolidine / acetonitrile
2: NH3 / H2O; dioxane / 20 °C
View Scheme
参考文献
Divakar, Kikkeri J.; Sawant, Chitra M.; Mulla; Zemse, Deepak V.; Sitabkhan, Sakina M.; Ross, Bruce S.; Sanghvi, Yogesh S.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1321 - 1325
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
study of deprotection rate (t1/2 = 27 s); Kinetics;
参考文献
Wagner; Pfleiderer
Helvetica Chimica Acta, 1997 , vol. 80, # 1 p. 200 - 212
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 18 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23382 A1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
1: ethyldiisopropylamine / tetrahydrofuran / 1 h / 25 °C
View Scheme
参考文献
Hayakawa, Yoshihiro; Kataoka, Masanori
Journal of the American Chemical Society, 1998 , vol. 120, # 48 p. 12395 - 12401
