6-氯-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 31 条）
反应条件
hydrogenchloride in tetrahydrofuran; methanol
参考文献
Japan Tobacco Inc.
Patent: US2008/64871 A1, 2008 ;
Location in patent: Page/Page column 58 ;
反应条件
sulfuric acid; potassium nitrate T=0 - 5°C; 1 h;
参考文献
Reddy Sastry; Srinivasa Rao; Krishnan; Rastogi; Jain; Kass Narayan
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1 p. 48 - 51
反应条件
in 1-methyl-pyrrolidin-2-one T=250°C; 20 h;
参考文献
Alantos Pharmaceuticals, Inc.,
Patent: US2006/173183 A1, 2006 ;
Location in patent: Page/Page column 104 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=250°C; Inert atmosphere;
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
反应条件
1: 1-methyl-pyrrolidin-2-one / 250 °C / Inert atmosphere
2: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C
3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
反应条件
triethylamine; trichlorophosphate
1.) acetonitrile, RT, 15 min, 2.) 5 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Reddy; Reddy, Pragati; Jagath Reddy; Srinivasa Rao
Heterocyclic Communications, 2003 , vol. 9, # 5 p. 503 - 506
反应条件
1: Lawesson's reagent
2: dimethylformamide / Heating
3: cyclodehydration
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Krishnan, V. S. H.; Joshi, P. P.; Naidu, M. U. R.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1279 - 1283
反应条件
bromine; acetic acid
T=20°C;
参考文献
Hanson, James R.; Richards, Lisa; Rozas, Panteleimon
Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1120 - 1128
反应条件
(i) aq. NaOH, (ii) /BRN= 471606/, aq. NaOH; Multistep reaction;
参考文献
Drain; Daly; Davy; Horlington; Howes; Scruton; Selway
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 9 p. 684 - 693
反应条件
(i) aq. NaOH, (ii) /BRN= 607485/, aq. NaOH; Multistep reaction;
参考文献
Drain; Daly; Davy; Horlington; Howes; Scruton; Selway
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 9 p. 684 - 693
