3,3-二甲氧基-2-甲基丙酸甲酯合成路线 （共 11 条）
反应条件
1: methacrylic acid methyl ester With bromine
T=0 - 20°C; 2 h;
2: sodium methylate in methanol
1 h; Heating / reflux;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2003/236397 A1, 2003 ;
Location in patent: Page 4-5 ;
反应条件
titanium tetrachloride in methanol
T=-78°C;
参考文献
Gawronski, Jacek K.
Tetrahedron Letters, 1984 , vol. 25, # 24 p. 2605 - 2608
反应条件
zinc in benzene
6 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2007/70433 A2, 2007 ;
Location in patent: Page/Page column 42-43 ;
WO 2007/070433 A2
反应条件
toluene-4-sulfonic acid in methanol
2.5 h; Heating;
参考文献
Torii, Sigeru; Inokuchi, Tsutomu; Kubota, Minoru
Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 4157 - 4160
反应条件
1: methacrylic acid methyl ester With bromine
T=20°C; 2 h;
2: sodium methylate in methanol
T=25°C; 16 h; Further stages. Title compound not separated from byproducts.;
参考文献
Jeong, Eun Jeong; Kang, Eun Joo; Sung, Lee Taek; Hong, Sung Kil; Lee, Eun
Journal of the American Chemical Society, 2002 , vol. 124, # 49 p. 14655 - 14662
反应条件
titanium tetrachloride in acetonitrile
T=-30°C;
参考文献
Gawronski, Jacek K.
Tetrahedron Letters, 1984 , vol. 25, # 24 p. 2605 - 2608
反应条件
copper(l) chloride; palladium dichloride in ethylene glycol dimethyl ether
参考文献
Bull, Steven D.; Davies, Stephen G.; Garner, A. Christopher; Kruchinin, Dennis; Key, Min-Suk; Roberts, Paul M.; Savory, Edward D.; Smith, Andrew D.; Thomson, James E.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 15 p. 2945 - 2964
反应条件
in methanol
Dehydrobromination; addition; 1 h; Heating;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
1: 93 percent / Et4NClO4 / 15 °C / electrolyse (carbon plate electrodes)
2: 80 percent / p-TsOH / methanol / 2.5 h / Heating
View Scheme
参考文献
Torii, Sigeru; Inokuchi, Tsutomu; Kubota, Minoru
Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 4157 - 4160
反应条件
in methanol
T=25°C; 16 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Walkup, Robert D.; Obeyesekere, Nihal U.
Synthesis, 1987 , # 7 p. 607 - 611
