3, 3-二苯基-2,3-环氧丙酸甲酯合成路线 （共 10 条）
反应条件
1: p-toluenesulfonic acid monohydrate / methanol / 5 h / 20 °C / |Large scale 2: potassium hydroxide / methanol / 66 - 94 °C / |Large scale 3: tert-butyl methyl ether; methanol / |Reflux; |Large scale 4: Li amide / N,N-dimethyl-formamide / 16 h / 20 - 30 °C / |Large scale View Scheme
参考文献
Jansen; Knopp; Amberg; Bernard; Koser; Mueller; Muenster; Pfeiffer; Riechers
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 16 - 22
反应条件
1.1: 0.25 h 1.2: 0.04 h / 20 - 55 °C 2.1: sodium hydroxide; water / 1.5 h / 90 - 95 °C 3.1: (S)-(-)-α-methyl-4-nitro-benzylamine / tert-butyl methyl ether; acetone / 13 h / 10 - 55 °C / Resolution of racemate View Scheme
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala; ADIBHATLA, Kali Satya Bhujanga Rao; BALINA, Veera Swamy; KASA, Srinivasu; NANNAPANENI, Venkaiah Chowdary
Patent: WO2012/17441 A1, 2012 ;
反应条件
boron trifluoride diethyl etherate T=0°C; 0.333333 h;
参考文献
Riechers, Hartmut; Albrecht, Hans-Peter; Amberg, Willi; Baumann, Ernst; Bernard, Harald; Boehm, Hans-Joachim; Klinge, Dagmar; Kling, Andreas; Mueller, Stefan; Raschack, Manfred; Unger, Liliane; Walker, Nigel; Wernet, Wolfgang
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2123 - 2128
反应条件
boron trifluoride-diethyl ether complex in methanol; ethyl acetate
参考文献
BASF Aktiengesellschaft
Patent: US6103732 A1, 2000 ;
US 6103732 A
反应条件
1.1: 0.25 h 1.2: 0.04 h / 20 - 55 °C 2.1: sodium hydroxide; water / 1.5 h / 90 - 95 °C View Scheme
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala; ADIBHATLA, Kali Satya Bhujanga Rao; BALINA, Veera Swamy; KASA, Srinivasu; NANNAPANENI, Venkaiah Chowdary
Patent: WO2012/17441 A1, 2012 ;
反应条件
1: benzophenone in toluene
0.25 h;
2: With sodium methylate in toluene
T=-10 - -5°C; 0.25 h;
3: chloroacetic acid methyl ester in toluene
T=-10 - -5°C; 1.5 h;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala; ADIBHATLA, Kali Satya Bhujanga Rao; BALINA, Veera Swamy; KASA, Srinivasu; NANNAPANENI, Venkaiah Chowdary
Patent: WO2012/17441 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
[Ni(2,2'-bipyridine)3(2+)][BF4(1-)]2; tetrabutylammomium bromide; zinc dibromide in dichloromethane; N,N-dimethyl-formamide
Ambient temperatureelectrolysis (carbon fiber cathode, zinc rod anode);
参考文献
Conan, Annie; Sibille, Soline; Perichon, Jacques
Journal of Organic Chemistry, 1991 , vol. 56, # 6 p. 2018 - 2024
反应条件
1: 1.) LDA / 1.) THF, hexane, -80 deg C, 5 min, 2.) from -80 deg C to room temp.
2: CH2Cl2
View Scheme
参考文献
Johnson, Carl R.; Bade, Thomas R.
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1205 - 1212
反应条件
in dichloromethane
Yield given;
参考文献
Johnson, Carl R.; Bade, Thomas R.
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1205 - 1212
反应条件
in benzene
20 h; Ambient temperatureIrradiationdifferent benzophenones and haloketene acetals; Product distributionMechanism;
参考文献
Ooms, Pieter; Hartmann, Willy
Tetrahedron Letters, 1987 , vol. 28, # 37 p. 4271 - 4274
