1,4-双(叔丁氧羰基)哌嗪合成路线 （共 5 条）
反应条件
amberlyst-15
T=20°C; 0.05 h; Neat (no solvent);
参考文献
Zeng, Hongyao; Li, Yongjia; Shao, Huawu
Synthetic Communications, 2012 , vol. 42, # 1 p. 25 - 32
反应条件
sodium hydroxide in water; tert-butyl alcohol
T=25°C; 1 h;
参考文献
Wu; MacCoss; Ikeler; Hirshfield; Arison; Tolman
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1559 - 1563
参考文献
Varala, Ravi; Nuvula, Sreelatha; Adapa, Srinivas R.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8283 - 8286
反应条件
1: Piperazine-2-carboxylic acid hydrochloride With potassium hydroxide in methanol
T=20°C; 1 h;
2: di-tert-butyl dicarbonate in 1,4-dioxane; water
T=20°C;
参考文献
Wu, Guosheng; Zhao, Hua; Luo, Robert G.; Wei, Dean; Malhotra, Sanjay V.
Enantiomer, 2001 , vol. 6, # 6 p. 343 - 345
反应条件
1: 80 percent / I2 / 0.5 h / 20 °C
2: 82 percent / I2 / 1 h / 20 °C
View Scheme
参考文献
Varala, Ravi; Nuvula, Sreelatha; Adapa, Srinivas R.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8283 - 8286
