6-({[5-(二甲基氨基)-1-萘基]磺酰基}氨基)己酸合成路线 （共 4 条）
反应条件
1: With sodium hydrogencarbonate; triethylamine in water; acetone
1 h;
2: With hydrogenchloride; water in acetone
pH=3;
参考文献
GEORGETOWN UNIVERSITY
Patent: WO2009/79375 A1, 2009 ;
Location in patent: Page/Page column 50-51 ;
WO 2009/079375 A1
反应条件
sodium hydroxide in 1,4-dioxane; water
T=20°C; pH=10; 4 h;
参考文献
Hermetter, Albin; Scholze, Hubert; Stuetz, Arnold E.; Withers, Stephen G.; Wrodnigg, Tanja M.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1339 - 1342
反应条件
1: 100 percent / triethylamine / CH2Cl2 / 2 h / 20 °C
2: 85 percent / aq. NaOH / H2O; dioxane / 4 h / 20 °C / pH 10
View Scheme
参考文献
Hermetter, Albin; Scholze, Hubert; Stuetz, Arnold E.; Withers, Stephen G.; Wrodnigg, Tanja M.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1339 - 1342
反应条件
1: 100 percent / triethylamine / CH2Cl2 / 2 h / 20 °C
2: 85 percent / aq. NaOH / H2O; dioxane / 4 h / 20 °C / pH 10
View Scheme
参考文献
Hermetter, Albin; Scholze, Hubert; Stuetz, Arnold E.; Withers, Stephen G.; Wrodnigg, Tanja M.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1339 - 1342
