1,2-二溴-4-三氟甲苯合成路线 （共 14 条）
反应条件
2,2,6,6-tetramethyl-piperidine; n-butyllithium; bromine; zinc(II) chloride in tetrahydrofuran; hexane
T=-100 - 25°C;
参考文献
Menzel, Karsten; Fisher, Ethan L.; DiMichele, Lisa; Frantz, Doug E.; Nelson, Todd D.; Kress, Michael H.
Journal of Organic Chemistry, 2006 , vol. 71, # 5 p. 2188 - 2191
反应条件
bromine; iron
T=55 - 70°C;
参考文献
Simons; Ramler
Journal of the American Chemical Society, 1943 , vol. 65, p. 389,390
反应条件
antimony(V) pentachloride; bromine
Einleiten von Chlor;
参考文献
Bachman; Lewis
Journal of the American Chemical Society, 1947 , vol. 69, p. 2022
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McBee; Sanford; Graham
Journal of the American Chemical Society, 1950 , vol. 72, p. 1649
反应条件
hydrogen bromide; sodium nitrite
Erwaermen der Reaktionsloesung mit Kupfer-Pulver;
参考文献
Tarrant; Lilyquist
Journal of the American Chemical Society, 1953 , vol. 75, p. 3034
反应条件
1: acetic acid; bromine
2: aqueous hydrobromic acid; sodium nitrite / Erwaermen der Reaktionsloesung mit Kupfer-Pulver
View Scheme
参考文献
Tarrant; Lilyquist
Journal of the American Chemical Society, 1953 , vol. 75, p. 3034
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile
参考文献
Doyle,M.P. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 2426 - 2431
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=50°C; 18 h; Inert atmosphere;
参考文献
Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 536 - 539
反应条件
1: [Ir2(OMe)2(1,5-cyclooctadiene)2]; dtbpy / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere
2: potassium fluoride / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 536 - 539
反应条件
sulfur(IV) fluoride; hydrogen fluoride; bromine
T=100°C; 7 h; Yield given. Yields of byproduct given;
参考文献
Kunshenko, B. V.; Omarov, V. O.; Muratov, N. N.; Mikhailevskii, S. M.; Yagupol'skii, L. M.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 1.2 p. 108 - 112
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 1 p. 125 - 129
参考文献
Dorai,C.S.; Damodaran,V.
Indian Journal of Chemistry, 1973 , vol. 11, p. 1000 - 1002
