3-氨基-5-甲基噻吩-2-羧酸甲酯合成路线 （共 3 条）
反应条件
1: (E,Z)-crotononitrile With pyridine; chlorine T=0 - 13°C; 2: 2-mercaptoacetic acid methyl ester With potassium carbonate in methanol T=10 - 20°C; 5 h;
参考文献
PFIZER INC.
Patent: WO2007/23382 A2, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/023382 A2
反应条件
1: T=180°C; 2.5 h; 2: With sodium hydroxide; water 3: With acetic acid in water
参考文献
Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP2003131 A1, 2008 ;
Location in patent: Page/Page column 64 ;
EP 2003131 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=0 - 20°C; 1.5 h;
参考文献
Gillespie, Paul; Michoud, Christophe; Rupert, Kenneth Carey; Thakkar, Kshitij Chhabilbhai
Patent: US2012/238569 A1, 2012 ;
Location in patent: Page/Page column 56 ;
