6-氯苯并二氢吡喃-4-胺合成路线 （共 4 条）
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
2: sulfuric acid / -10 - 0 °C
3: hydrogenchloride; water / ethanol / 72 h / Reflux
View Scheme
参考文献
Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
反应条件
1: sulfuric acid / -10 - 0 °C
2: hydrogenchloride; water / ethanol / 72 h / Reflux
View Scheme
参考文献
Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
反应条件
1: sulfuric acid / 1 h / 20 °C
2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3: sulfuric acid / -10 - 0 °C
4: hydrogenchloride; water / ethanol / 72 h / Reflux
View Scheme
参考文献
Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
反应条件
1.1: potassium hydroxide / ethanol; water / Reflux
1.2: pH 1
2.1: sulfuric acid / 1 h / 20 °C
3.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
4.1: sulfuric acid / -10 - 0 °C
5.1: hydrogenchloride; water / ethanol / 72 h / Reflux
View Scheme
参考文献
Goffin, Eric; Lamoral-Theys, Delphine; Tajeddine, Nicolas; De Tullio, Pascal; Mondin, Ludivine; Lefranc, Florence; Gailly, Philippe; Rogister, Bernard; Kiss, Robert; Pirotte, Bernard
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 834 - 844
