bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; 1 h;

1: 2-methyl-4-propyl-hex-1-en-5-yne With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 2: With tBuOOLi in tetrahydrofuran; toluene T=-78 - 0°C; 2.5 h; 3: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; toluene T=-78 - 0°C;

1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C 1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C 1.3: tetrahydrofuran; petroleum ether / 20 °C 2.1: aq. NaOH / methanol; tetrahydrofuran 3.1: LiHMDS; t-BuOOLi / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C 3.2: 80 percent / tetrahydrofuran; toluene / -78 - 0 °C View Scheme