4-(4-氨基苯基)-2,3-二氢-1H-异吲哚-1-酮合成路线 （共 5 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether
T=90°C; Suzuki coupling;
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509
反应条件
1: 94 percent / NBS; Bz2O2 / benzene
2: 87 percent / aq. NH3 / tetrahydrofuran
3: 75 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 90 °C
View Scheme
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509
反应条件
1: Et3N
2: 94 percent / NBS; Bz2O2 / benzene
3: 87 percent / aq. NH3 / tetrahydrofuran
4: 75 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 90 °C
View Scheme
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509
反应条件
1: SOCl2
2: Et3N
3: 94 percent / NBS; Bz2O2 / benzene
4: 87 percent / aq. NH3 / tetrahydrofuran
5: 75 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 90 °C
View Scheme
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509
反应条件
1: 87 percent / aq. NH3 / tetrahydrofuran
2: 75 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 90 °C
View Scheme
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509
