1-(3-溴-5-异噁唑)-乙酮合成路线 （共 9 条）
反应条件
chromium(VI) oxide in water; acetic acid
T=15°C; 40 h;
参考文献
Chiarino; Napoletano; Sala
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 43 - 46
反应条件
magnesium in tetrachloromethane; ethanol; water
参考文献
Zambon S.p.A.
Patent: US4276299 A1, 1981 ;
反应条件
in water; acetic acid
参考文献
Zambon S.p.A.
Patent: US4772719 A1, 1988 ;
反应条件
sodium hydrogencarbonate in dichloromethane
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Amici, Marco De; Micheli, Carlo De; Carrea, Giacomo; Spezia, Sandro
Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2646 - 2650
反应条件
Yield given. Multistep reaction;
参考文献
Chiarino; Fantucci; Carenzi; Della Bella; Frigeni; Sala
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 440 - 453
反应条件
bromine; acetic acid in chloroform
T=48 - 50°C;
参考文献
Chiarino; Grancini; Frigeni; Biasini; Carenzi
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 600 - 605
反应条件
in tetrachloromethane; water
参考文献
Zambon S.p.A.
Patent: US4276299 A1, 1981 ;
反应条件
bromine in chloroform; acetic acid
T=48 - 50°C; 0.166667 h; Yield given;
参考文献
Chiarino; Fantucci; Carenzi; Della Bella; Frigeni; Sala
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 440 - 453
反应条件
1: bromine / CHCl3; acetic acid / 0.17 h / 48 - 50 °C
2: 97.3 percent / NaBH4 / methanol / 1 h / 20 °C
3: 14.25 g / sodium hydride / benzene / 3 h / Ambient temperature
4: 8 g / ethanol / 16 h / Heating
View Scheme
参考文献
Amici, Marco De; Micheli, Carlo De; Carrea, Giacomo; Spezia, Sandro
Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2646 - 2650
