2-氟-5-溴吡啶合成路线

1093092-64-86-溴-1,2,4-噻唑并[4,3-a]吡啶-3(2H)-硫酮

参考文献

WO2013/38362 A1, ;

US2013/245002 A1, ;

参考文献

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RENSLO, Adam R.; GALLARDO-GODOY, Alejandra; SILBER, B. Michael; PRUSINER, Stanley B.; GILES, Kurt; LI, Zhe; NEITZ, R. Jeffrey
Patent: WO2013/33037 A2, 2013 ;
Location in patent: Paragraph 0755 ;

766-11-02-氟-5-溴吡啶

361147-22-02-氟-3-苯基吡啶

参考文献

Sutherland, Andrew; Gallagher, Timothy
Journal of Organic Chemistry, 2003 , vol. 68, # 8 p. 3352 - 3355

766-11-02-氟-5-溴吡啶

1111637-74-15-溴-2-氟-3-乙酰基吡啶

参考文献

LEWIS, Richard T.; ALLEN, Jennifer R.; CHENG, Yuan; CHOQUETTE, Deborah; EPSTEIN, Oleg; GUZMAN-PEREZ, Angel; HARRINGTON, Paul E.; HUA, Zihao; HUNGATE, Randall W.; HUMAN, Jason Brooks; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; MINATTI, Ana Elena; OLIVIERI, Philip; ROMERO, Karina; RUMFELT, Shannon; RZASA, Robert M.; SCHENKEL, Laurie; STELLWAGEN, John; WHITE, Ryan; XUE, Qiufen; ZHENG, Xiao; ZHONG, Wenge
Patent: US2014/107109 A1, 2014 ;

766-11-02-氟-5-溴吡啶+

57260-71-61-Boc-哌嗪

153747-97-84-BOC-1-(5-溴-2-吡啶基)哌嗪

参考文献

Astellas Pharma Inc.
Patent: US2012/184520 A1, 2012 ;
Location in patent: Page/Page column 17 ;

766-11-02-氟-5-溴吡啶+

124-40-3二甲胺

26163-07-55-溴-2-二甲基氨基吡啶

参考文献

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RENSLO, Adam R.; GALLARDO-GODOY, Alejandra; SILBER, B. Michael; PRUSINER, Stanley B.; GILES, Kurt; LI, Zhe; NEITZ, R. Jeffrey
Patent: WO2013/33037 A2, 2013 ;
Location in patent: Paragraph 0751 ;

1003-09-42-溴噻吩+

766-11-02-氟-5-溴吡啶

1132832-80-42-氟-5-(2-噻吩基)吡啶

参考文献

Fillers, Walter Ferdinand Maria; Broeckx, Rudy Laurent Maria; Nieste, Patrick Hubert J.; Hatsuda, Masanori; Yoshinaga, Masahiko; Yada, Mitsuhiro
Patent: US2010/99883 A1, 2010 ;
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US 20100099883 A1

766-11-02-氟-5-溴吡啶

780749-63-52-氟-5-(1H-咪唑-5-基)吡啶

参考文献

Burger, Matthew T.; Lin, Xiaodong; Chu, Daniel T.; Hiebert, Christy; Rico, Alice C.; Seid, Mehran; Carroll, Georgia L.; Barker, Lynn; Huh, Kay; Langhorne, Mike; Shawar, Ribhi; Kidney, Jolene; Young, Kelly; Anderson, Scott; Desai, Manoj C.; Plattner, Jacob J.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1730 - 1743

766-11-02-氟-5-溴吡啶

827628-42-2

参考文献

VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; XU, Zhenrong; HIMMELSBACH, Frank; ECKHARDT, Matthias
Patent: WO2011/159760 A1, 2011 ;
WO 2011/159760 A1

766-11-02-氟-5-溴吡啶+

97-94-9三乙基硼

871325-13-2

参考文献

Mitsubishi Tanabe Pharma Corporation
Patent: EP2390254 A1, 2011 ;
Location in patent: Page/Page column 66 ;
EP 2390254 A1