3,4-二氯-5-羟基-5H-呋喃-2-酮合成路线 （共 40 条）
参考文献
Li, Jian-Xiao; Liang, Hao-Ran; Wang, Zhao-Yang; Fu, Jian-Hua
Monatshefte fur Chemie, 2011 , vol. 142, # 5 p. 507 - 513
反应条件
scandium tris(trifluoromethanesulfonate) in ethylene glycol dimethyl ether T=-20 - 20°C; Mukaiyama aldol reaction; 6 h; Product distribution; Further Variations:Solvents;
参考文献
Angell, Paul; Zhang, Ji; Belmont, Daniel; Curran, Timothy; Davidson, James G.
Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2029 - 2032
反应条件
In(OSO2CF3)3 in toluene Friedel-Crafts hydroxyalkylation; Heating;
参考文献
Zhang, Ji; Blazecka, Peter G.; Curran, Timothy T.
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2611 - 2615
反应条件
sulfuric acid in benzene 20 h; Heating;
参考文献
Fishbein, Paul L.; Moore, Harold W.
Synthetic Communications, 1989 , vol. 19, # 19 p. 3283 - 3288
参考文献
Homer et al.
Journal of the Chemical Society, 1948 , p. 2191,2194
反应条件
sodium acetate; monohydrazine sulfate in ethanol; water 4 h; Heating;
参考文献
Ma, Chen; Liu, Shao-Jie; Xin, Liang; Falck; Shin, Dong-Soo
Tetrahedron, 2006 , vol. 62, # 38 p. 9002 - 9009
反应条件
1: 1,1-dimethylethylhydrazine hydrochloride With sodium hydroxide in water; toluene T=20°C; 2: 3,4-dichloro-5-hydroxyfuran-2(5H)-one in water; toluene T=20°C; 3: With acetic acid in water; toluene T=45 - 50°C; 18 h;
参考文献
WO2011/97649 A2, ;
Page/Page column 151 ;
反应条件
hydrogenchloride; water 3 h; Reflux;
参考文献
Suree, Nuttee; Yi, Sung Wook; Thieu, William; Marohn, Melanie; Damoiseaux, Robert; Chan, Albert; Jung, Michael E.; Clubb, Robert T.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7174 - 7185
反应条件
1: 3-trifluoromethyl-aniline With hydrogenchloride; sodium nitrite in water T=-5 - 0°C; 0.5 h; 2: With hydrogenchloride; tin(ll) chloride in water T=0°C; 2 h; 3: 3,4-dichloro-5-hydroxyfuran-2(5H)-one in water T=80 - 90°C;
参考文献
Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735
反应条件
diboron trioxide in methanol T=180 - 185°C; 15 h;
参考文献
Kress, Thomas J.; Szymanski, Edward
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1721 - 1722
