4,6-二氯-4H-嘧啶-5-酮肟合成路线 （共 3 条）
反应条件
1: thionyl chloride / chloroform / 2 h / 20 °C 2: ammonia / tetrahydrofuran / 0.83 h View Scheme
参考文献
AMGEN INC.
Patent: US2011/152296 A1, 2011 ;
Title/Abstract Full Text Show Details
AMGEN INC.
Patent: US2011/245257 A1, 2011 ;
Title/Abstract Full Text Show Details
AMGEN INC.; CUSHING, Timothy D.; LOHMAN, Julia Winslow; SHIN, Youngsook
Patent: WO2012/68343 A1, 2012 ;
WO 2012/068343 A1
反应条件
thionyl chloride T=0 - 20°C; 3.5 h;
参考文献
ARENA PHARMACEUTICALS INC.
Patent: WO2004/65380 A1, 2004 ;
Location in patent: Page 151-152 ;
WO 2004/065380 A1
反应条件
hydroxylamine hydrochloride; sodium acetate in water; ethyl acetate
2 h;
参考文献
ARENA PHARMACEUTICALS INC.
Patent: WO2004/65380 A1, 2004 ;
Location in patent: Page 151-152 ;
WO 2004/065380 A1
