3,4-二氢-4-氧代-2-喹唑啉羧酰胺合成路线 （共 6 条）
反应条件
ammonium hydroxide
T=70°C; 2 h;
参考文献
Varadi, Andras; Horvath, Peter; Kurtan, Tibor; Mandi, Attila; Toth, Gerg; Gergely, Andras; Koekoesi, Jozsef
Tetrahedron, 2012 , vol. 68, # 50 p. 10365 - 10371
反应条件
1: 38 percent / Heating
2: 87 percent / NH3 / ethanol / Ambient temperature
View Scheme
参考文献
Joshi, Vidya; Chaudhari, Rajendra P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 602 - 604
参考文献
Griess
Chemische Berichte, 1885 , vol. 18, p. 2420
反应条件
sodium hydroxide
1.) ethanol, 2 h, NH3 gas; 2.) 10 min; Yield given. Multistep reaction;
参考文献
Osman, A.N.; Botros, S.
Pharmazie, 1980 , vol. 35, # 7 p. 439
参考文献
Griess
Chemische Berichte, 1885 , vol. 18, p. 2420
反应条件
trichlorophosphate
3 h;
参考文献
PFIZER INC.
Patent: WO2006/72831 A1, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/072831 A1
